Effects of BDNF and delivery vehicle on sensorimotor function following dMCAo. (A) Sensorimotor deficits, measured using the 28-point Neuroscore (28-PN), improve following treatment with hydrogel-only, BDNF-only, or hydrogel + BDNFHIGH. Improvement measured as percent recovery compared to day seven. (B) Performance on the adhesive removal test (ART) contralateral to injury. Contact time recovery index significantly improved in the hydrogel + BDNFHIGH group on days 42 and 56. (C) Removal time recovery index significantly improved in the hydrogel + BDNFHIGH group on day 42. Vehicle (n = 4), BDNF-only (n = 7–9), hydrogel-only (n = 7–9), hydrogel + BDNFLOW (n = 7–9), and hydrogel + BDNFHIGH (n = 6–11). Error bars indicate the mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001.