Table 5.
Parameters, determination coefficients and statistical significance of dissolution kinetics models.
| Formulation | MDT (min) | DE (%) | Mathematical Model | ||
|---|---|---|---|---|---|
| Zero Order | Korsmeyer–Peppas | Hixson–Crowell | |||
| (Constant Release) | (Diffusion Based Release) | (Erosion Based Release) | |||
| Raw BCL (not processed) | 19.55 | 5.58 |
k = 0.1037 Q0 = 2.4571 r2 = 0.9594 p = 0.0035 |
k = 1.0895 n = 0.5002 r2 = 0.9981 p < 0.0001 |
k = 0.0117 Q0 = 2.66 r2 = 0.9036 p = 0.0114 |
| BCL (E) | 20.65 | 22.39 |
k = 0.4455 Q0 = 8.9816 r2 = 0.9686 p = 0.0024 * |
k = 3.8641 n = 0.5362 r2 = 0.9991 p < 0.0001 * |
k = 0.0199 Q0 = 10.02 r2 = 0.9131 p = 0.0096 * |
| BCL (SD) | 15.99 | 53.05 |
k = 0.8489 Q0 = 27.25 r2 = 0.9040 p = 0.0130 |
k = 12.2261 n = 0.4501 r2 = 0.9827 p = 0.0011 * |
k = 0.0216 Q0 = 28.13 r2 = 0.8440 p = 0.0263 |
| BCL-PVP 1:1 (SD) | 6.28 | 70.30 |
k = 0.4905 Q0 = 55.90 r2 = 0.5796 p = 0.1350 |
k = 35.4591 n = 0.2164 r2 = 0.8413 p = 0.0358 |
k = 0.0104 Q0 = 55.06 r2 = 0.5611 p = 0.1540 |
| BCL-PVP 2:1 (SD) | 3.60 | 83.93 |
k = 0.1530 Q0 = 82.11 r2 = 0.5043 p = 0.1790 |
k = 73.9170 n = 0.0512 r2 = 0.7916 p = 0.0464 |
k = 0.0027 Q0 = 82.02 r2 = 0.5014 p = 0.1840 |
| BCL-PVP 1:1 (E) | 7.65 | 73.17 |
k = 0.5099 Q0 = 58.37 r2 = 0.4847 p = 0.1920 |
k = 35.4333 n = 0.2287 r2 = 0.7469 p = 0.0769 |
k = 0.0107 Q0 = 56.933 r2 = 0.4759 p = 0.2100 |
| BCL-PVP 2:1 (E) | 5.19 | 79.11 |
k = 0.2097 Q0 = 75.53 r2 = 0.8494 p = 0.0260 |
k = 67.22 n = 0.0632 r2 = 0.9917 p = 0.0003 * |
k = 0.0037 Q0 = 75.55 r2 = 0.8394 p = 0.0284 |
r2, determination coefficient; MDT, mean dissolution time; DE, dissolution efficiency; k, dissolution rate constant; Q0, percent of drug dissolved at time t = 0; n is the release exponent; p is the probability of ANOVA test for similarity (* <0.01).