Table 1.
The landmark of key drugs delivery technologies to the market.
| Year | Drug Delivery System | |
|---|---|---|
| 1952 | The first sustained-release technology Spansule® | [10] |
| 1956 | The first pressurized metered dose inhaler (MDI) | |
| 1969 | The first dry powder inhalation (DPI) | [11] |
| 1979 | The first transdermal patch Transdermal Scop® | [21] |
| 1982 | The first recombinant human insulin Humulin R® | [22] |
| 1984 | The first Biodegradable microsphere Vivitrol® | [23] |
| 1986 | The first injection microsphere Decapeptyl® | [24] |
| 1989 | The first Push-Pull Osmotic Pump product Procardia XL® | [25] |
| 1995 | The first FDA-approved liposome Doxil® | [13] |
| 2005 | The first FDA-approved nanoparticle Abraxane® | [14] |
| 2006 | The first FDA-approved botanical medicine VeregenTM | [26] |
| 2015 | The first FDA-approved 3D print drug Spritam® | [27] |
| 2017 | The first FDA-approved gene therapy Kymriah® | [28] |
| 2017 | The first FDA-approved digital drug Abilify MyCite® | [29] |