A	immunocompetent Acanthamoeba spp. infected mice
ADAM	adamalysin-like proteinases
AM 22	amoebic strain no. 22
AML	acute myeloid leukemia
AS	immunosuppressed Acanthamoeba spp. infected mice
BBB	blood brain barrier
BCA	bicinchoninic acid
C	immunocompetent uninfected control group mice
cAMP	cyclic adenosine monophosphate
CNS	central nervous system
COX-2	cyclooxygenase-2
CS	immunosuppressed uninfected mice
CSF	cerebrospinal fluid
Dpi	day post infection
GAE	granulomatous amebic encephalitis
GCL	granular cell layer
HIV	human immunodeficiency virus
IHC	Immunohistochemistry
IL-1	interleukin 1
IL-6	interleukin 6
IL-23	interleukin 23
LTP	long term potentiation
MMPs	matrix metalloproteinases
MMP-2	matrix metalloproteinase-2
MMP-9	matrix metalloproteinase-9
MPS	methylprednisolone sodium succinate
NK	natural killers
PBS	phosphate-buffered saline
PDGF	platelet-derived growth factor
PGE2	Prostaglandin E2
PKDL	Post-kala-azar dermal leishmaniasis
PyrCL	pyramidal cell layer
SD	standard deviation
TACE/ADAM17	ADAM metallopeptidase domain 17
TGF-β	transforming growth factor—β
TIMP	tissue inhibitor of metalloproteinase
TIMP-1	tissue inhibitor of metalloproteinase-1
TIMP-3	tissue inhibitor of metalloproteinase-3
TNF	tumor necrosis factor
TNF-α	tumor necrosis factor—α