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. 2018 Nov 30;19(12):3813. doi: 10.3390/ijms19123813

Figure 4.

Figure 4

The bL compound suppresses cell proliferation and migration in an NQO1-dependent manner. (A) Cell proliferation was determined by counting the cell numbers of MDA-MB-231 and two independent clones of NQO1 stable cells (NQO1 #1 and #2) after treatment with bL (2 µM) for 24 h. The data are presented as means ± SEM; n = 3; ** p < 0.01, N.S: not significant. (B) A wound healing assay was performed as described in Section 4, using MDA-MB-231 and two independent clones of NQO1 stable cells (NQO1 #1 and #2) treated with bL (2 µM) for 18 h. Images were taken using a new hybrid microscope (Echo, San Diego, CA, USA). The scale bar is 230 μm. The black dash line indicates boundary that cells migrate. (C) A cell migration assay was performed with Transwell cell culture chambers as described in Section 4, using MDA-MB-231 and NQO1 stable cells treated with bL (2 µM) for 7 h. Images were taken using a new hybrid microscope (Echo, San Diego, CA, USA). The scale bar is 230 μm.