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. 2018 Dec 14;19(12):4048. doi: 10.3390/ijms19124048

Table 1.

Reported interactions between grapefruit juice and selected anti-neoplastic drugs.

Antineoplastic Drug Metabolism Interaction Ref.
Etoposide Metabolized by CYP3A4 Decrease etoposide exposure (area under the concentration time curve (AUC) 26.2% ↓) [39]
Nilotinib Metabolized by CYP3A4 Increase nilotinib exposure (Cmax 60% ↑, AUC 29% ↑)
No increase in adverse events		 [40]
Sunitinib Metabolized by CYP3A4 Increase sunitinib exposure (Cmax 10.9% ↑, AUC 11% ↑)
No increase in toxicity		 [41]