Scheme 2.
Reagents and conditions: (i) 2-cyanoethyl 3-oxobutanoate, selected aminocrotonate, isopropanol, reflux; 20 h; (ii) LiOH, rt, 16 h; (iii) N-(2,6-dimethylphenyl)-2-[4-(2-hydroxy-ethylpiperazin-1-yl)]acetamide, CDI or DCC, THF, 120 °C, 1 h.
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