Table 3.
Association of circulating irisin with cardiovascular risk factors and metabolic alterations.
| Author | Sample | Insulin | HOMA | Glucose | TG | HDL-c | LDL-c | TC | MS | Leptin | Others |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Löffler 2015 [11] | n = 105 (46 boys) Germany NW (n = 20), OW/OB (n = 64) 8–21 y-o and OB (n = 58 (23 boys)) 7–17 y-o. | 0 | 0 | 0 | 0 | 0 | 0 | 0 | N/A | N/A | N/A |
| Al-Daghri 2014 [28] | n = 133 (76 boys) Saudi Arabia 9–15 years y-o. OB (n = 30). | 0 | 0 | − | 0 | 0 | 0 | 0 | N/A | 0 | (+) with ANG II |
| Reinehr 2015 [10] | n = 60 Germany 10–15 y-o NW (n = 20 (10 boys)), OB (n = 40 (20 boys)) | + | + | 0 | + | − | + | N/A | N/A | N/A | (+) with 2-h OGTT and DBP |
| Binay 2017 [7] | n = 120 Turkey 10–18 y-o NW (n =30), OB (n = 90). | + | + | + | N/A | N/A | N/A | N/A | N/A | N/A | (+) with SBP in OB |
| Catli 2016 [5] | n = 66 Turkey 8–15 y-o. OB (n = 20 (20 boys)), NW (n = 30 (16 boys)). | + | + | 0 | 0 | − | 0 | 0 | N/A | 0 | N/A |
| Nigro 2017 [20] | n = 27 (19 boys) OB Italy 4–13 y-o, NW (n = 13 (4 boys)). | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (−) with adiponectin |
| Blüher 2014 [27] | n = 65 OB (35 boys) 7–18 y-o. | 0 | 0 | 0 | N/A | N/A | N/A | N/A | N/A | N/A | No relation with adiponectin, leptin, or resistin |
| De Meneck 2018 [29] |
n = 87 (47 boys) Brazi l6–12 y-o. NW (n = 63), OW/OB (n = 24) |
+ | + | + | + | − | N/A | 0 | N/A | N/A | (+) with SBP and DBP in the entire cohort, (+) with EPCs |
| Viitasalo 2015 [30] |
n = 444 (247 boys) Finland 6–9 y-o. NW (n = 388), OW/OB (n = 55). |
N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | (+) with unfavorable fatty acid profile |
| Shim 2018 [9] | n = 96 (56 boys) Korea 6 to 10 y-o. NW (n = 54), OW (n = 16), OB (n = 26). | N/A | N/A | − | (−) in OW/OB |
0 | 0 | 0 | − | N/A | (+) with SBP and DBP in OB/OW |
| Palacios-González 2015 [6] | n = 85 (40 boys) Mexico 8–10 y-o. NW (n = 25), OW (n = 23), OB (n = 37). | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | + | N/A |
DBP (diastolic blood pressure), HDL-c (high-density lipoprotein cholesterol), LDL-c (low-density lipoprotein cholesterol), N/A (not available), NW (normal weight), OB (obese), OGGT (oral glucose tolerance test), OW (overweight), PBF (percent body fat), SBP (systolic blood pressure), TC (total cholesterol, + (positive correlation), − (negative correlation), 0 (no correlation).