Table 1.
Metabolic pathways significantly changed in AD compared to control as assessed by MSEA.
| Pathway | Total 1 | Hits 2 | Expect 3 | Fold Change 4 | p Value | Hit Metabolites |
|---|---|---|---|---|---|---|
| Methionine Metabolism | 43 | 11 | 3.44 | 3.20 | <0.001 | AMP, Adenosine, N,N-Dimethylglycine, Choline, Gly, Ser, Met, Homoserine, Sarcosine, Putrescine, Methionine sulfoxide |
| Glycine and Serine Metabolism | 59 | 11 | 4.72 | 2.33 | 0.005 | AMP, Creatine, N,N-Dimethylglycine, Gly, Ala, Thr, Ser, Sarcosine, O-Phosphoserine, Met, ADP |
| Purine Metabolism | 74 | 11 | 5.93 | 1.85 | 0.028 | Adenine, AMP, Adenosine, Gly, Guanine, Guanosine, Hypoxanthine, Xanthine, dAMP, ADP-ribose, ADP |
| Thiamine Metabolism | 9 | 3 | 0.72 | 4.16 | 0.029 | AMP, Thiamine, ADP |
| Alanine Metabolism | 17 | 4 | 1.36 | 2.94 | 0.041 | AMP, Gly, Ala, ADP |
1 Total numbers of metabolites that corresponded in each pathway. 2 Observed numbers of metabolites that derived from given dataset in each pathway. 3 Expected observed numbers of metabolites that are calculated by given dataset in each pathway. 4 Hits/expect.