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. 2018 Dec 17;19(12):4078. doi: 10.3390/ijms19124078

Figure 4.

Figure 4

Pharmaceutical Doxycycline (DOX) Inhibits Cellular Redox Signaling Induced by MAA-Adduct Formation. HEK293 cells containing a Nrf2/ARE-responsive element driving luciferase expression were incubated for 24 h in the presence or absence of 1 mg/mL pharmaceutical DOX and either 25 µg/mL ALB, or 2 mM MDA and 1 mM AA, or 25 µg/mL ALB, 2 mM MDA, and 1 mM AA. Significantly decreased with the addition of DOX (* p < 0.0001). Significantly increased compared to ALB + Vehicle (# p < 0.0001) N = 5.