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. 2018 Dec 9;19(12):3957. doi: 10.3390/ijms19123957

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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A hypothesis of the miR-23a~27a~24-2 cluster regulatory role in bovine adipocyte adipogenesis. In this study, miRNA agomir repressed adipogenesis (A) and miRNA antagomir increased adipogenesis (B). Since most of the proved target genes (DCN, G6PD, and LPL) were strong anti-adipogenic effects (solid blue lines), we hypothesize that there were other pro-adipogenic target genes apart from GPAM and DGAT2 that contribute to miR-23a~27a~24-2 cluster-regulated preadipocyte differentiation (dotted green lines).