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. 2018 Dec 9;19(12):3957. doi: 10.3390/ijms19123957

Figure 8.

Figure 8

FGF11 is targeted by the miR-23a~27a~24-2 cluster. (A) Prediction of miR-23a, miR-27a, and miR-24-2 seed sequence in the FGF11 3’UTR region using TargetScan software and miRanda. (B) Sequence alignments of miR-24-2 seed sequence showed high conservation among mammals. (C,D) Structure of FGF11-3’UTR luciferase reporter vector with wild or mutant miRNA seed sequence. The mutant sequence was marked in red. (E,F) Luciferase analysis showed that FGF11 was directly targeted by miR-24-2 (F) but not miR-27a (E). Error bars represent SEM. “**” represents p < 0.01.