Table 3.

Marine plant-isolated polybromodiphenyl ether derivatives with in vitro PTP1B inhibitory effects.

No.	Compound/Structure	Marine Species	Outcomes/Enzymes	Reference
24	2-(3’,5’-Dibromo-2’-methoxyphenoxy)-3,5-dibromophenol	Indonesian marine sponge Lamellodysidea herbacea	PTP1B inhibition (IC50 = 0.9 µM) Huh-7 inhibition (IC50 = 32 µM)	[45]
25	3,5-Dibromo-2-(3’,5’-dibromo-2’-methoxyphenoxy)-1-methoxybenzene	Indonesian marine sponge Lamellodysidea herbacea	PTP1B inhibition (IC50 = 1.7 µM) Huh-7 inhibition (IC50 = 48 µM)	[45]
26	3,5-Dibromo-2-(3’,5’-dibromo-2’ -methoxyphenoxy)phenylethanoate	Indonesian marine sponge Lamellodysidea herbacea	PTP1B inhibition (IC50 = 0.6 µM)	[45]
27	3,5-Dibromo-2-(3’,5’-dibromo-2’ -methoxyphenoxy)phenylbutanoate	Indonesian marine sponge Lamellodysidea herbacea	PTP1B inhibition (IC50 = 0.7 µM)	[45]
28	3,5-Dibromo-2-(3’,5’-dibromo-2’ -methoxyphenoxy)phenylhexanoate	Indonesian marine sponge Lamellodysidea herbacea	PTP1B inhibition (IC50 = 0.7 µM)	[45]
29	3,5-Dibromo-2-(3’,5’-dibromo-2’ -methoxyphenoxy)phenyl benzoate	Indonesian marine sponge Lamellodysidea herbacea	PTP1B inhibition (IC50 = 1.0 µM)	[45]