Table 5.
Marine plant-isolated sterols with in vitro PTP1B inhibitory effects.
| No. | Compound/Structure | Marine Species | Outcomes/Enzymes | Reference |
|---|---|---|---|---|
| 36 | 24-Hydroperoxy-24-Vinylcholesterol
|
Marine invertebrates South China Sea sponge Xestospongia testudinaria Lamarck (Petrosiidae) | - | [68] |
| 37 | 29-Hydroperoxystigmasta-5,24(28)-dien-3-ol
|
Marine invertebrates South China Sea sponge Xestospongia testudinaria Lamarck (Petrosiidae) | PTP1B inhibition (IC50 = 5.8 µg/mL) |
[68] |
| 38 | 5α,8α-Epidioxycholest-6-en-3β-ol
|
Sea urchin Glyptocidaris crenularis A. Agassiz (Glyptocidaridae) | - | [68] |
| 39 | 5α,8α-Epidioxycholest-6,22-dien-3β-ol
|
Sponge Mycale spp. (Mycalidae) | - | [68] |
| 40 | 5α,8α-Epidioxy-ergosta-6,22-dien-3β-ol
|
Gorgonian Dichotella gemmacea Milne Edwards and Haime (Ellisellidae) | - | [68] |
| 41 | 3β-Hydroxycholest-5-en-25-acetoxy-19-oate
|
Gorgonian Dichotella gemmacea Milne Edwards and Haime (Ellisellidae) | - | [68] |
| 42 | Fucosterol (24-ethylidene cholesterol)
|
Brown algae Eisenia bicyclis and Ecklonia stolonifera |
Non-competitive type inhibitor against PTP1B | [67,68,69] |