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. 2018 Dec 15;23(12):3334. doi: 10.3390/molecules23123334

Table 6.

Marine plant-isolated terpenes with in vitro PTP1B inhibitory effects.

No. Compound/Structure Marine Species Outcomes/Enzymes Reference
43 Dysidine
Inline graphic 		Sponge Dysidea villosa PTP1B inhibition (IC50 = 6.7 μM) [46,71]
44 Dysidavarone A
Inline graphic 		South China Sea sponge Dysidea avara PTP1B inhibition (IC50 = 10.0 μM) [70]
45 Dehydroeuryspongin A
Inline graphic 		Marine Sponge Euryspongia spp. PTP1B inhibition (IC50 = 3.6 μM) [72]
46 Sarsolilide A
Inline graphic 		Hainan soft coral Sarcophyton trocheliophorum Marenzeller PTP1B inhibition (IC50 = 6.8 μM) [73]
47 Sarsolilide B
Inline graphic 		Hainan soft coral Sarcophyton trocheliophorum Marenzeller PTP1B inhibition (IC50 = 27.1 μM) [73]
48 Methyl sarcotroates A and B
Inline graphic 		Hainan soft coral Sarcophyton trocheliophorum PTP1B inhibition (IC50 = 7.0 μM) [73]
49 9-Oxa-2-azabicyclo-[3,3,1]-nona-3,7-diene derivative
Inline graphic 		Sponge Hippospongia lachne of Yongxing Island PTP1B inhibition (IC50 = 5.2 μM) [75]
50 2-(Aminomethylene) hepta-3,5-dienedial moiety connected with farnesyl group at C-7
Inline graphic 		Sponge Hippospongia lachne of Yongxing Island PTP1B inhibition (IC50 = 8.7 μM) [75]
51 Hopane-6α,22-diol
Inline graphic 		Antarctic lichen Lecidella carpathica PTP1B inhibition (IC50 =3.7 μM)
TCPTP inhibition (IC50 = 8.4 μM)
SHP-2 inhibition (IC50 > 68 μM)
LAR inhibition
(IC50 > 68 μM)
CD45 inhibition (IC50 > 68 μM)		 [76]
52 Stellettin G
Inline graphic 		Hainan sponge Stelletta spp. PTP1B inhibition (IC50 = 4.1 μM) [77]

TCPTP, T-cell protein tyrosine phosphatase; SHP-2, src homology phosphatase-2; LAR, leukocyte antigen-related phosphatase; CD45, CD45 tyrosine phosphatase.