Figure 2.

TNF-α receptors, pathways and different types of signals—schematic diagram. TNF-α has an ability to induce apoptosis, cell survival or inflammation depending on selected pathway. Tumor necrosis factor α (TNF-α); tumor necrosis factor α receptor (TNFR); tumor necrosis factor receptor type 1-associated death domain (TRADD); Fas-associated protein with death domain (FADD); tumor necrosis factor receptor-associated factor (TRAF); mitogen-activated protein kinase kinase kinase (MEKK); c-jun N-terminal kinase (JNK); activator protein 1 (AP-1); receptor interacting protein (RIP); mitogen-activated protein kinases (MAPK); nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB); NF-κ-B-inducing kinase (NIK); I κB kinase (IKK).; T-bar as a drug - binding point interaction.