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CXCL8(1-77), [Cit5]CXCL8(1-77) and CXCL8(6-77) are no biased ligands for CXCR1 and CXCR2. Bias plot of CXCR1 (A) and CXCR2 (B), represented as ΔΔLog for Gαi signaling (cAMP reduction) against β-arrestin 2 recruitment of the different CXCL8 variants compared to natural CXCL8(1-77) ± SEM [63].
