Table 1.
Manipulation of YAP expression and its effect on apoptosis.
| Cancer | Method | YAP Expression | Apoptosis | PMID |
|---|---|---|---|---|
| Esophagus | shRNA | Decreased | Increased | 27307755 [32] |
| Lung | shRNA | 25665005 [33] | ||
| Breast | shRNA | 28892790 [18] | ||
| Stomach | siRNA | 27073556 [34] | ||
| Stomach | siRNA | 21805037 [35] | ||
| Liver | siRNA | 23419361 [36] | ||
| Liver | siRNA | 27323827 [37] | ||
| Liver | siRNA | 29928445 [38] | ||
| Pancreas | siRNA | 27738325 [39] | ||
| Pancreas | siRNA | 27669292 [40] | ||
| Pancreas | siRNA | 22396793 [41] | ||
| Colon/Rectum | siRNA | 29439714 [42] | ||
| Colon/Rectum | shRNA | 29241219 [43] | ||
| Colon/Rectum | shRNA | 29037225 [15] | ||
| Colon/Rectum | siRNA | 26944315 [44] | ||
| Colon/Rectum | siRNA | 29512779 [45] | ||
| Ovarian | siRNA | 29848699 [46] | ||
| Prostate | siRNA | 26126522 [47] | ||
| Rhabdomyosarcoma | shRNA | 26496700 [48] | ||
| Lung | cDNA | Increased | Decreased | 20219076 [52] |
| Liver | cDNA | 24482231 [49] | ||
| Liver | cDNA | 27359056 [50] | ||
| Liver | cDNA | 29928445 [38] | ||
| Pancreas | cDNA | 27738325 [39] | ||
| Colon/Rectum | cDNA | 29037225 [15] | ||
| Colon/Rectum | cDNA | 29042987 [51] | ||
| Thyroid | siRNA | Decreased | - | 28804541 [54] |
-: YAP gene silencing failed to promote cell apoptosis.