Table 2.

Molecules regulate Hippo-YAP signaling and apoptosis.

Molecule	Target	YAP	Apoptosis	PMID
a. Activators of YAP, which impede apoptosis
TFAP2C	MST1/2	Increases nuclear YAP	Decreased	29439714 [42]
WBP5	MST2	Increases nuclear YAP	Decreased	27336605 [68]
lncRNA MALAT1	LATS1	Increases cellular YAP	Decreased	29215734 [69]
STK38L	LATS2	Increases cellular YAP	Decreased	29108249 [70]
IKBKE	LATS1/2	Decreases phosphorylation of YAP	Decreased	29048430 [71]
Itch	LATS1	Decreases phosphorylation of YAP	Decreased	21383157 [73]
S100 A1	LATS1	Decreases phosphorylation of YAP	Decreased	29901195 [74]
Ajuba	LATS1/2	Decreases phosphorylation of YAP	Decreased	20303269 [75]
lncRNA PCGEM1	RhoA	Increases cellular YAP	Decreased	29949791 [78]
CREB	YAP	Increases YAP gene transcription	Decreased	24482231 [49]
b. Activators of YAP, which induce apoptosis
RASSF1A	YAP	Increases nuclear YAP	Increased	17889669 [8]
EGR-1	YAP	Forms a complex with YAP	Increased	19137013 [91]
c. Inhibitors of YAP, which induce apoptosis
GPCRs	PKA	Phosphorylates YAP at serine 381	Increased	23644383 [97]
RASSF6	MST1/2	Decreases cellular YAP	Increased	29964010 [100]
CRB-3	LATS1/2	Increases phosphorylation of YAP	Increased	28079891 [102]
AMPK	YAP	Increases phosphorylation of YAP	Increased	25751140 [104]
Fbxw7	YAP	Increases YAP degradation	Increased	24884509 [107]
miR520c-3p	YAP	Decreases YAP gene expression	Increased	27633306 [108]
miR132	YAP	Decreases YAP gene expression	Increased	27633306 [108]
Hsa-miR-138-2-3p	YAP	Decreases cellular YAP	Increased	28533948 [109]
d. Inhibitors of YAP, which impede apoptosis
deltaNp63	YAP	Controversy in YAP gene expression	Decreased	28923839 [111]
CABYR	YAP	Increases phosphorylation of YAP	Decreased	26843620 [7]
PI3K/AKT	YAP	Increases phosphorylation of YAP	Decreased	12535517 [114]

Phosphorylates YAP at serine 127.