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. 2018 Dec 17;19(12):4081. doi: 10.3390/ijms19124081

Figure 1.

Figure 1

Screening of novel therapeutic targets for pulmonary arterial hypertension and schematic representation of the role of selenoprotein P (SeP). Volcano plots of gene expression variations in PAH-PASMCs and control PASMCs. Blue plots represent probes for SeP. Dashed lines represent an adjusted P value of 0.05 and ± 1-fold change. PAH-PASMCs, pulmonary artery smooth muscle cells harvested from patients with pulmonary arterial hypertension (PAH); ApoER2, apolipoprotein E receptor 2; ERK1/2, extracellular signal regulated kinases 1 and 2; ETC, electron transport chain; FOXO3a, forkhead box protein O3a; GSH, glutathione; GSSG, oxidized glutathione; HIF-1α, hypoxia inducible factor 1α; PAH-PASMCs, pulmonary arterial hypertension-pulmonary artery smooth muscle cells; ROS, reactive oxygen species; SeP, selenoprotein P; TCA cycle, tricarboxylic acid cycle.