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New candidate molecules for novel targets in pulmonary hypertension.
| New Candidate Molecules | Novel Targets | References |
|---|---|---|
| Fasudil | Rho-kinase (human, inharation) | [134] |
| Fasudil | Rho-kinase (human, oral) | [72] |
| Fasudil | Rho-kinase (rodents) | [37] |
| Metformin | AMPK (mouse) | [25] |
| PPARα agonist (Fenofibrate, WY14643) | TAFI (mouse) | [126] |
| TAFIa inhibitor (carboxypeptidase inhibitor) | TAFI (mouse) | [126] |
| Sanguinarin | Selenoprotein P (rat) | [107] |
| Celastrol | Cyclophilin A and Basigin (mouse) | [85] |
