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PIK3KC2α and β are associated with clathrin-coated endocytic intermediates (1.) while PIK3K II and III participate in the local production of PtdIns3P at recycling endosomes (2.). PI3KC2α regulates priming and secretion of large dense core vesicles at chromaffin cells (3.) and PI3KC2α is required for Delta opioid receptor (δR) trafficking [4].
