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. 2018 Nov 28;23(12):3110. doi: 10.3390/molecules23123110

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Neferine induces G2/M cell cycle arrest in human neuroblastoma cells. (A,B) IMR32 cells were cultured at the described concentrations of neferine (A) or TMZ (B) for 24 h, and then flow cytometry analysis was used to determine the cell cycle distributions; (C,D) The quantification of cell cycle arrest in neferine-treated or TMZ-treated IMR32 cells was shown. Data are expressed as mean ± SD in three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 as compared with the non-treated control.

Neferine induces G2/M cell cycle arrest in human neuroblastoma cells. (A,B) IMR32 cells were cultured at the described concentrations of neferine (A) or TMZ (B) for 24 h, and then flow cytometry analysis was used to determine the cell cycle distributions; (C,D) The quantification of cell cycle arrest in neferine-treated or TMZ-treated IMR32 cells was shown. Data are expressed as mean ± SD in three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 as compared with the non-treated control.