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. 2018 Dec 11;19(12):3983. doi: 10.3390/ijms19123983

Figure 6.

Figure 6

Multimerin-2 and EMILIN-2 expression impact on the angiogenic response in the gastric cancer environment. (A) Representative images of the tubes formed by HUVEC cells placed on MATRIGEL® and challenged with conditioned media from AGS cells following the addiction of recombinant EMILIN-2 (E2) or an equal volume of PBS; scale bar = 100 μm. (B) Quantification of the total of tubes, total branching points, total tubes length and total loops of the experiment reported in A; [px]: pixels. (C) Representative images of the tubes formed by HUVEC cells placed on MATRIGEL® and challenged with conditioned media from AGS following transduction with the control (siCNTR) or Multimerin-2 specific (siMMRN2) siRNA adenoviral constructs; scale bar = 100 μm. (D) Quantification of the total tubes, total branching points, total tubes length and total loops of the experiment reported in C. Graphs represent the mean ± SD; p values were obtained using the paired Student’s t-test.