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. 2018 Nov 22;19(12):3708. doi: 10.3390/ijms19123708

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical appearance of total MET (A), phospho-MET (B), matriptase (C) and HAI-1 (D) in serial tissue sections of high-grade urothelial carcinoma (patient 23, ×200 magnification). Dominant expression of total MET (A) and matriptase (C) is observed. Phosphorylation of MET is also upregulated (B); however, downregulation is observed in part (arrows). In contrast, increased expression of HAI-1 is observed in the area with downregulated phospho-MET (D, allows). This case shows a representative pattern of reciprocal expression of HAI-1 and phospho-MET.