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. 2018 Nov 14;10(4):231. doi: 10.3390/pharmaceutics10040231

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Stability study of SLNs containing DBC, prepared by high-pressure (H-P) or sonication (U-S) methods, during storage at 4 °C for 240 days. Stability is measured in terms of particle size (A) and zeta potential values (B). Statistical analysis: comparison between days 1 and 240 after preparation (ANOVA) and between the processes used to produce the SLN (Student’s t-test, p < 0.05). p < 0.001 (***); p < 0.01 (**); p < 0.05 (*); not significant (ns). Difference between days 1 and 240: a. SLN_CPDBC/U-S vs. SLN_CPDBC/H-P (60 days of storage); b. SLN_CPDBC/U-S vs. SLN_CPDBC/H-P (180 days of storage). Zeta potential: c. SLN_MMDBC/U-S vs. SLN_MMDBC/H-P (1 day of storage); d. SLN_MMDBC/U-S vs. SLN_MMDBC/H-P (90 days of storage); e. SLN_CPDBC/U-S vs. SLN_CPDBC/H-P (30 days of storage); f. SLN_CPDBC/U-S vs. SLN_CPDBC/H-P (60 days of storage); g. SLN_CPDBC/U-S vs. SLN_CPDBC/H-P (240 days of storage). Data are shown as mean ± standard deviation (n = 3).