Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Impact of APOE4 and TREM2 R47H variants on AD pathology. Lipidated ApoE binds Aβ for its internalization or transport to other cell types. ApoE4 exhibits lower Aβ-binding affinity than ApoE3. TREM2 in microglia mediates ApoE-driven Aβ clearance. It is also required for microglial phagocytosis and inhibition of the immune response. The genetic variant on this gene (TREM2 R47H) has been shown to exhibit lower ligand-binding affinity.
