Figure 1.

Progression of cortical gray matter loss in patients with childhood-onset schizophrenia (COS) (n = 70) relative to age-, sex-, and scan interval-matched healthy individuals (n = 72). Brain templates illustrate areas of significant thinning in patients with COS in a ‘front-to-back’ pattern from adolescence to young adulthood (age 12–24 years). Side bar shows t statistic with threshold to control for multiple comparisons. Figure 1 is reproduced from Gogtay [26] by permission of Oxford University Press, adapted by Greenstein et al. [27] by permission of John Wiley and Sons.