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. 2018 Sep 20;10(4):163. doi: 10.3390/pharmaceutics10040163

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The effect of CPEs in Pal-GH gel formulations on the MTZ release (A) and skin permeation (B) profiles. Significant differences in MTZ release were observed among all formulations except between F5_MTZ and F5_IPM-MTZ (* p < 0.05), and in MTZ permeation between F5_PG-MTZ and F5_EtOH-MTZ or F5_TRANS-MTZ; and between F5_IPM-MTZ and F5_EtOH-MTZ or F5_TRANS-MTZ (* p < 0.05). Symbols: ■: F5_PG-MTZ, ●: F5_IPM-MTZ, ▲: F5_MTZ, ◆: F5_DMSO-MTZ, ◇: F5_EtOH-MTZ, ○: F5_TRANS-MTZ (Mean ± S.E., n = 3–4).