Table 1.
Composition of the N-Palmitoyl-Glycine-Histidine (Pal-GH) gel formulations and metronidazole (MTZ) solution with or without a chemical enhancer prepared in this experiment. IPM = isopropyl myristate; PG = propylene glycol; ethanol; DMSO = dimethyl sulfoxide; and TRANS = isopropyl myristate.
| Formulation Code | Pal-GH Conc. (Premix) | Chemical Penetration Enhancer |
|---|---|---|
| F2.5MTZ | 2.5% | No enhancer |
| F5MTZ | 5% | No enhancer |
| F5IPM-MTZ | IPM 10% | |
| F5PG-MTZ | Propylene glycol 4% | |
| F5DMSO-MTZ | DMSO 5% | |
| F5EtOH-MTZ | Ethanol 20% | |
| F5TRANS-MTZ | isopropyl myristate 10% | |
| F10MTZ | 10% | No enhancer |
| Aqueous solution | No enhancer | |
| IPMMTZ | IPM 10% | |
| PGMTZ | Propylene glycol 4% | |
| DMSOMTZ | DMSO 5% | |
| EtOHMTZ | Ethanol 20% | |
| TRANSMTZ | Transcutol 10% |