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. 2018 Nov 22;19(12):3711. doi: 10.3390/ijms19123711

Figure 2.

Figure 2

MiRNA biogenesis. MiRNA biogenesis starts in the nucleus with a long hairpin transcript called pri-miRNA that is further processed to a smaller transcript of 70 nucleotides. After is exported in the cytoplasm, pre-miRNA is enzymatically processed to single-strand mature miRNA of about 21–23 nucleotides. When it is incorporated in the enzymatically machinery called the RNA-induced silencing complex (RISC), mature miRNA guide the RISC to silence the specific mRNA transcripts, either by their degradation of by translation repression.