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CRC metastasis in the liver through CRC circulating tumor cells (CTCs), mediated by miRNAs transported by CRC-delivered exosomes (miRNA-TEX). CXCR4 and CCR6 chemokine receptors are responsible for liver organotropism of miRNA-TEX, while the miRNAs released in the liver are responsible for preparing the secondary pre-metastatic niche by inducing the pro-inflammatory and pro-tumorigenic signals.
