Table 1.

MiRNAs and their mRNA targets associated with the development, progression and metastasis of CRC.

Key Signaling Pathways	miRNAs	Targets	Targeting Effects	Ref.
Activation of Wnt/ß-catenin pathway	oncomiR (High Expression)—Gain of Function
	miR-21	CTNNB1, TGFBR2, PIK3CA, BRAF, ZFHX3, SFRP1	Tumor development, proliferation, progression	[30,31]
	miR-135a/b	APC	proliferation	[32]
	miR-494	APC	Proliferation, tumorigenesis	[33]
	miR-155	CTNNB1	Invasion; metastasis	[34]
	miR-146a	NUMB	Progression, stemness	[35]
	miR-522	DACH1	Proliferation, migration	[36]
	miR-19a	APC, CTNNB1, c-Myc, PTEN, TIA1	Proliferation, tumorigenesis, proliferation, invasion, progression, angiogenesis	[37,38]
	miR-224	GSK3β, sFRP-2	Proliferation, metastasis	[39]
	miR-103a miR-1827	APC, APC2, CTNNB1, WNT3a	Cell cycle progression, reduced apoptosis	[40]
	miR-574-5p	Qki 6/7	Proliferation, tumorigenesis differentiation, angiogenesis	[41]
	TS-miR (Low/Reduced Expression)—Loss of Function
	miR-137	CTNNB1, WNT3a	Cell cycle progression	[40]
	miR-23b	FzD-7	Proliferation, progression, invasion, metastasis	[42]
	miR-7	YY-1	Proliferation, reduced apoptosis, cell cycle progression	[43]
	miR-93	SMAD-7, CTNNB1	Proliferation, progression	[44]
	miR-185	MYC, CCND1	Proliferation, progression	[45]
Activation of EGFR signaling pathway	oncomiR (High Expression)—Gain of Function
	miR-20, miR-21, miR-130b	PTEN	Progression, invasion, metastasis	[46]
	miR-26b	PTEN, WNT5A	Proliferation, EMT, metastasis	[47]
	miR-182, miR-135b	ST6GALNAC2, PI3K/AKT	Proliferation, invasion	[48]
	TS-miR (Low/Reduced Expression)—Loss of Function
	miR-43, miR-145	CD44, KLF5, KRAS, BRAF	Proliferation, migration	[49]
	Let-7	KRAS	tumorigenesis	[50]
	miR-19a	KRAS, VEGFA	Proliferation, angiogenesis	[51]
	miR-181d	PEAK1	Proliferation, invasion, migration, metastasis	[52]
	miR-30a	KRAS, ME1	CRC developmnet	[53]
	miR-217	MAPK1, KRAS, Raf-1	Tumor growth, apoptosis	[54]
	miR-487b	LRP6, KRAS	Metastasis	[55]
	miR-16	KRAS	Proliferation, invasion, apoptosis	[56]
	miR-384	KRAS, CDC42	Invasion, migratiuon, metastasis	[57]
	mirR-125a-3p	FUT5-FUT6	Proliferation, migration, invasion, angiogenesis	[58]
Inactivation of TGF-ß signaling pathway	oncomiR (High Expression)—Gain of Function
	miR-135b	TGFBR2	Progression, inhibiting of apoptosis	[59]
	miR-301a	TGFBR2	Migration, invasion, metastasis	[60]
	miR-20-5p	SMAD4	EMT, Invasion, metastasis	[61]
	miR-224	SMAD4	Invasion, metastasis	[62]
Suppressing of TP53 function	oncomiR (High Expression)—Gain of Function
	miR-125b	TP53	CRC progression	[63]
	miR-504	TP53	CRC progression	[64]
	miR-29b, miR-30	TP53	CRC progression	[65]
	miR-24	TP53	CRC pogressin	[66]
	miR-518c, miR-638	TP53, PTEN	CRC progression, invasion, metastasis	[67]
	TS-miR (Low/Reduced Expression)—Loss of Function
	miR-638	SOX2, TSPAN1	EMT, invasion, migration, proliferation	[68,69]
	miR-34a	SIRT1	Proliferation, reducing apoptosis	[70]