Table 2.

MiRNAs and their mRNA targets associated with regulation and induction of epithelial to mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), supporting CRC invasion and metastasis.

Key Signaling	miRNAs	Targets	Function	Ref.
Regulation of EMT	oncomiR (High Expression)—Gain of Function
	miR-675-5p	SNAIL	EMT, invasion, metastasis	[83]
	TS-miR (Low/Reduced Expression)—Loss of Function
	miR-34a/b/c	SNAIL, SLYG, ZEB1, BIM1, CD44, CD133, c-MYC	EMT, invasion, metastasis, MET	[84,85]
	miR-375	SP1, MMP2, SNAIL, CDH1, VIM, CDH2, CTNNB1	EMT, invasion, metastasis	[86]
	miR-374	CCND1, ZEB1, CDH2 VIM, SLUG, SNAIL	EMT, proliferation, invasion, migration, liver metastasis	[87]
	miR-200c	ZEB1, ETS1, FLT1, ASCL2	EMT-MET plasticity, invasion, migration, liver metastasis	[88,89]
	miR-429	ONECUT2, ZEB1, ZEB2	EMT, invasion, migration	[90]
	miR-335, miR-132, miR-192	ZEB2	EMT, Invasion, metastasis	[91,92,93]
Inducing of EMT	oncomiR (High Expression)—Gain of Function
	miR-20a	SMAD4, MMP2, MMP9	EMT, migration, metastasis	[94,95]
	miR-4775	SMAD7/TGF-ß	EMT, invasion, metastasis	[96]
	miR-1269	SMAD7, HOXD10	EMT, invasion, metastasis	[97]
	miR-21	NRF2, SMAD7	EMT, invasion, metastasis	[98]
	miR-150	CREB	EMT, invasion, migration	[99]
	miR-194	MMP2	EMT, invasion, migration	[100]
	TS-miR (Low/Reduced Expression)—Loss of Function
	miR-320c	SOX4, FOXM1, FOXQ1	EMT, proliferation, migration, tumorigenesis	[101]
	miR-187	SOX4, NT5E, PTK6	EMT, invasion, metastasis	[102]
	miR-34a	CTNNB1, c-Met ZEB1, ZEB2, SNAIL	Progression, EMT, liver metastasis	[103,104]
	miR-145	SIP1, CTNNB1, TCF4, VIM, SNAIL	Proliferation, migration, EMT, invasion, metastasis	[105]
	miR-29b	BCL9L, TCF7L2, SNAI1, PGRN	Cell growth, EMT, angiogenesis, invasion, migration	[106,107]
	Let-7c	MMP11	Cell migration and invasion	[108]