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. 2018 Dec 7;23(12):3233. doi: 10.3390/molecules23123233

Table 5.

Box–Behnken design with independent variables and measured response.

Source Sum of Squares df Mean Square F Value p-Value Prob > F
Model 2022.273 14 144.4481 229.5803 <0.0001 significant
A-Water content 1.872498 1 1.872498 2.976078 0.1065
B-Time 80.8396 1 80.8396 128.4834 <0.0001
C-Pressure 75.90223 1 75.90223 120.6362 <0.0001
D-Liquid-solid ratio 37.33898 1 37.33898 59.34518 < 0.0001
AB 4.378975 1 4.378975 6.959778 0.0195
AC 17.9536 1 17.9536 28.53477 0.0001
AD 4.840466 1 4.840466 7.693255 0.0149
BC 11.18712 1 11.18712 17.78039 0.0009
BD 109.843 1 109.843 174.5803 <0.0001
CD 41.42853 1 41.42853 65.84495 <0.0001
A2 439.4122 1 439.4122 698.3853 <0.0001
B2 716.8069 1 716.8069 1139.266 <0.0001
C2 516.0715 1 516.0715 820.2247 <0.0001
D2 853.7272 1 853.7272 1356.882 <0.0001
Residual 8.808564 14 0.629183
Lack of Fit 7.89223 10 0.789223 3.445136 0.1223 not significant
Pure Error 0.916333 4 0.229083
Cor Total 2031.081 28
R-Squared 0.995663
Adj R-Squared 0.991326
Pred R-Squared 0.976913