Table 2.
Transcriptional regulation of autophagy through AMPK phosphorylation. H, human; M, mouse; R, rat.
| Transcription Factor | Phosphorylation Site(s) | Target Gene (s) | Ref. |
|---|---|---|---|
| CHOP | Ser30(H, M, R) | ATG5, MAP1LC3B | [96] |
| FOXO3 | Thr179(H) Ser399(H) Ser413(H) Ser555(H) Ser588(H) Ser626(H) |
ATG4B, GABARAPL1, ATG12, ATG14, GLUL, MAP1LC3,
BECN1, PIK3CA, PIK3C3, ULK1, BNIP3, FBXO32 |
[89] |
| HSF1 | Ser121(H, M, R) | ATG7 | [97] |
| Nrf2 | Ser558(H, M) | SQSTM1 | [98] |
| p53 | Ser15(H, R) | AEN, DRAM1, BAX, IGFBP3, BBC3, C12orf5, PRKAB1, PRKAB2, CDKN2A, SESN1, SESN2, DAPK1, BCL2, MCL1 | [99] |
| p73 | Ser426(H) | ATG5, DRAM1, ATG7, UVRAG | [100] |