Table 1.
The polymer composition (% w/w), drug content (DC) and encapsulation efficiency (EE) of loaded microspheres.
| Microsphere Codes | Methyl-β-Cyclodextrin | Chitosan | DC (%) | EE (%) | dvs (µm) | SPAN |
|---|---|---|---|---|---|---|
| MC100 | 100 | - | 4.25 ± 0.05 a | 88.78 ± 0.98 a | 3.49 ± 0.10 | 2.20 |
| MC90 | 90 | 10 | 4.25 ± 0.01 a | 88.66 ± 0.22 a | 2.74 ± 0.09 | 1.85 |
| MC50 | 50 | 50 | 4.20 ± 0.07 a | 87.87 ± 1.53 a | 6.79 ± 1.84 b,c | 2.24 |
| MC10 | 10 | 90 | 3.81 ± 0.05 | 80.91 ± 1.13 | 6.55 ± 1.04 b,c | 2.09 |
| CH100 # | - | 100 | 4.75 ± 0.06 | 95.0 ± 1.20 | 6.14 ± 0.84 b,c | 1.66 |
# Prepared as reference for in vivo studies [23]. a p < 0.05 MC10 versus MC100; versus MC90; versus MC50. b p < 0.05 MC100 versus CH100; versus MC50; versus MC10. c p < 0.05 MC90 versus CH100; versus MC50; versus MC10.