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Scheme of synthesis of lipoconjugates 3a–c (a–c show the structure of spacer used) (A) and structures of cholesterol-based polycationic amphiphile 2X3 and lipid helper DOPE used for liposomes preparation (B). Reagents and conditions: (i) 4-NO2C6H4OCOCl and Et3N, 24 °С, 11 h, then H2N-PEG-NH2, 24 °С, 1 h, 57–73%; (ii) Ac2O, Py, 24 °C, 6 h, 77–88%.
