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Biodistribution of Cy5.5-labeled siMDR complexed with liposomes P800, P1500, P2000 or L in SCID mice. (A,B) Lifetime fluorescence imaging of SCID mice (dorsal orientation view) 20 min (exposure time 20 s) (A) or 24 h (exposure time 60 s) (B) after i.v. injection. (C) Images of dissected organs of SCID mice at 24 h time point (h: heart, lu: lungs, li: liver, s: spleen, k: kidney). L/siRNA and P/siRNA lipoplexes were formed at N/P = 4/1; control: non-injected mice.
