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. 2018 Nov 27;23(12):3101. doi: 10.3390/molecules23123101

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Stimulation of the innate immune response by isRNA in complexes with PEGylated P and conventional L liposomes in vivo. СBA/LacSto mice were injected i.v. with isRNA (10 μg per mouse) in complex with liposomes (at the ratio N/P = 4/1). siRNA with scrambled sequence (siScr) was used as a control. (A) Serum IFN-α and (B) IL-6 (white columns) and TNF-α (black columns) levels were measured by ELISA 6 h after injection. The data represent means ± standard deviation (SD) calculated from measurements from at least three mice. The differences between mean values for isRNA/L and other preparations were considered statistically significant: * p < 0.05, ** p < 0.01 (Mann-Whitney U-test).