Table 1.
Hydrodynamic diameters, polydispersity index and cytotoxicity of PEG-containing cationic liposomes.
| Cationic Liposome 1 | PEG Lipoconjugate | Diameter, Mean, nm |
PI 2 | Living Cells 3, % |
|---|---|---|---|---|
| L | - | 95.7 ± 19.5 | 0.260 ± 0.055 | 72.2 ± 4.5 |
| P800 | 3a | 67.3 ± 15.3 | 0.207 ± 0.015 | 64.1 ± 5.6 |
| P1500 | 3b | 76.5 ± 13.5 | 0.226 ± 0.014 | 60.1 ± 1.1 |
| P2000 | 3c | 50.6 ± 12.7 | 0.245 ± 0.006 | 79.7 ± 13.2 |
1 Conventional liposomes 2X3:DOPE prepared at 1:1 molar ratio were designated as L. PEG-containing liposomes were designated as P. 2 PI: polydispersity index. 3 The amount of live HEK293 cells in the population after incubation in the presence of 80 μM liposomes for 24 h, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay data.