Table 2.
Hydrodynamic diameters, polydispersity index and ξ-potentials of lipoplexes formed by siRNA (siScr) and PEG-containing (P) or conventional (L) cationic liposomes.
| Cationic Liposomes | N/P | Diameter, nm | Polydispersity Index (PI) | ξ-Potential, mV |
|---|---|---|---|---|
| L | 1/1 | 2298.7 ± 320.4 | 0.459 ± 0.116 | 14.9 ± 1.8 |
| 2/1 | 276.1 ± 5.3 | 0.237 ± 0.038 | 46.4 ± 1.8 | |
| 4/1 | 206.0 ± 10.2 | 0.267 ± 0.042 | 45.3 ± 1.7 | |
| P800 | 1/1 | 246.5 ± 8.9 | 0.528 ± 0.049 | −23.1 ± 1.3 |
| 2/1 | 175.2 ± 22.6 | 0.305 ± 0.027 | 44.6 ± 1.2 | |
| 4/1 | 178.4 ± 3.4 | 0.334 ± 0.043 | 40.2 ± 0.6 | |
| P1500 | 1/1 | 836.1 ± 65.8 | 0.337 ± 0.021 | 30.1 ± 2.6 |
| 2/1 | 173.3 ± 6.8 | 0.353 ± 0.061 | 35.2 ± 3.6 | |
| 4/1 | 93.1 ± 4.1 | 0.235 ± 0.030 | 39.6 ± 1.3 | |
| P2000 | 1/1 | 4038.3 ± 736.1 | 0.625 ± 0.264 | −1.3 ± 0.2 |
| 2/1 | 180.2 ± 8.4 | 0.303 ± 0.055 | 32.8 ± 1.4 | |
| 4/1 | 143.0 ± 7.1 | 0.328 ± 0.087 | 37.5 ± 3.2 |