Table 3.
Accumulation of Cy5.5-labeled siMDR complexed with liposome P800, P1500, P2000 or L formed at N/P of 4/1 in the organs of healthy SCID mice, 24 h after i.v. injection.
| Organ | Total Fluorescence of the Organ, RFU a | Total Florescence in the Organ Relative to the Total Fluorescence in All Organs, % | ||||||
|---|---|---|---|---|---|---|---|---|
| P2000 | P1500 | P800 | L | P2000 | P1500 | P800 | L | |
| Heart | 44.9 ± 1.9 | 14.1 ± 0.7 | 6.9 ± 0.4 | 9.7 ± 0.4 | 10.6 ± 0.4 | 2.6 ± 0.1 | 2.2 ± 0.1 | 2.5 ± 0.1 |
| Lungs | 112 ± 5.7 | 161.3 ± 9.2 | 85.3 ± 5.2 | 107.4 ± 5.8 | 26.5 ± 1.3 | 29.7 ± 1.7 | 27.8 ± 1.7 | 27.4 ± 1.5 |
| Liver | 65.6 ± 3.2 | 121 ± 7.1 | 72.6 ± 3.6 | 108.3 ± 5.7 | 15.5 ± 0.8 | 22.3 ± 1.3 | 23.7 ± 1.2 | 27.6 ± 1.5 |
| Spleen | 31.4 ± 1.4 | 90.7 ± 3.9 | 45.2 ± 3.3 | 53 ± 3.1 | 7.4 ± 0.3 | 16.7 ± 0.7 | 14.7 ± 1.1 | 13.5 ± 0.8 |
| Kidneys | 169.3 ± 9.5 | 155.8 ± 8.9 | 96.8 ± 5.8 | 114.4 ± 4.2 | 40 ± 2.2 | 28.7 ± 1.6 | 31.5 ± 1.9 | 29.1 ± 1.1 |
| Total | 423.2 ± 21.7 | 542.9 ± 29.8 | 306.8 ± 18.3 | 392.8 ± 19.2 | 100 | 100 | 100 | 100 |
Mean ± SD (n = 3). a RFU: relative fluorescence units.