Table 6.
Loading values of the lacquers (mg/mL) and results of diffusion studies conducted with ciclopirox olamine through nails and hooves. The content from OnyTEC and Ciclochem was taken from the product information.
| Enhancer | Ciclopirox Olamine Concentration(mg/mL) | Hoof | Nail | ||
|---|---|---|---|---|---|
| Flux mg/day·cm2 | % Dose Delivered | Flux mg/day·cm2 | % Dose Delivered | ||
| AC 5% | 24.31 ± 3.45 | 0.734 | 1.95 | 0.164 | 0.68 |
| CB 0.2 % | 22.50 ± 1.56 | 0.605 | 2.68 | ||
| PEG 5% | 23.81 ± 3.25 | 0.582 | 2.33 | ||
| PK 5% | 36.85 ± 1.54 | 0.409 | 0.70 | ||
| SLS 0.5% | 21.17 ± 2.19 | 0.181 | 0.86 | ||
| SLS 1 % | 23.47 ± 3.92 | 0.561 | 2.00 | 0.308 | 1.36 |
| SLS 5% | 26.45 ± 2.21 | 1.325 | 3.02 | ||
| LABRAFIL 5% | 17.89 ± 2.16 | 0.477 | 2.64 | ||
| LABRASOL 5% | 16.18 ± 3.19 | 0.507 | 3.14 | ||
| LAC 5% | 14.85 ± 2.19 | 0.555 | 2.68 | ||
| Ony-Tec | 80 | 0.158 | 0.21 | 0.011 | 0.09 |
| Ciclochem | 80 | 0.000 | 0.006 | ||