Figure 2.

The Gene Set Enrichment Analysis (GSEA) enrichment scores for space-flown vs. ground control mouse liver and kidney. GSEA calculates a score for the enrichment of an entire set of genes across a gene ontology (GO) pathway. A positive score indicates enrichment in the space-flown mice relative to the ground controls. In 764 of the 785 pathways analyzed, there was enrichment in both kidney and liver in response to spaceflight. The nine pathways that were upregulated in liver and downregulated in kidney are listed in the upper left corner and detailed in Table 1. The 12 pathways that were upregulated in kidney but downregulated in liver are listed on the lower right corner and detailed in Table 2.