Figure 4.

Mouse kidney pathways overexpressed in space. Functional gene networks that were upregulated in kidney in response to spaceflight. ClueGO Cytoscape visualizes the interactions of gene clusters in a functionally grouped network using enrichment maps. Nodes in the same cluster are assigned the same node color and node size indicates the number of mapped genes in each GO term. The node label is determined on the basis of common themes in the processes within the cluster. Bar graphs of the fold-change (FC) of individuals genes are shown on the right. Gene names highlighted in yellow were also overexpressed in mouse liver after spaceflight. Data in the bottom panel with orange and blue stripes applies to both the orange and blue clusters. Arrows mark the gene clusters that were also seen in Space-flown liver. Additional information on the clusters can be found in Supplemental Figure S2.