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. 2018 Dec 12;23(12):3302. doi: 10.3390/molecules23123302

Figure 3.

Figure 3

Impact of fucoidan on the induction of apoptosis in HNSCC cell lines: H103, FaDu, KB (a): 24 h incubation with fucoidan induces apoptosis in all tested cell lines (CTR—control, 0.5FV—half-fold of IC50 concentration, 1FV—IC50 concentration, 2FV—2-fold of IC50 concentration, PS—phosphatidylserine). The data are presented as an average ± standard deviation. (b): 24 h treatment with fucoidan down-regulates the levels of full-length PARP, BECN1, and CASP3 in H103 and FaDu cells. Fucoidan decreases the expression of PARP and BECN1 while up-regulating levels of CASP3 in KB cell line. (CTR—control, 0.5FV—half-fold of IC50 concentration, 1FV—IC50 concentration, 2FV—2-fold of IC50 concentration). The data are presented as mean ± standard deviation. p values lower than 0.05 were considered significant and are labeled by asterisks (*) for p < 0.05, (**) for p < 0.01, (***) for p < 0.001, and (****) for p ≤ 0.0001.