Figure 7.
In vivo antimalarial activity assays. (A) Kaplan–Meier plot for the in vivo assay of the effect on P. yoelii-infected mice (n = 5 animals/sample except for ARGO7-CQ, where one of the infections was not successful) of CQ administered orally at 5 mg kg−1 day−1, either as a free drug or polymer-conjugated. (B) Microscopic images of blood smears prepared on different days (D0 was the day of the first infection, and reinfection was on day 35), used to determine parasitemias in a P. yoelii-infected mouse treated with AGMA1-CQ.