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Bioactivation of pre-carcinogens mediated by CYP 1A2, 2A6 or 3A4 when combined with the three CPR hinge mutants. Bioactivation capacities were normalized with the one observed when CYPs were combined with WT CPR. (2AA: 2-aminoanthracene; IQ: 2-amino-3-methylimidazo(4,5-f)quinoline; NNdEA: N-nitrosodiethylamine; NNK: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; AfB1: aflatoxin B1).
