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. 2018 Dec 18;19(12):4102. doi: 10.3390/ijms19124102

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Factors associated with connection and perfusion of transplanted tissues. Using tissue engineering technology, 3D tissues were formed and transplanted. Factors affecting host–donor vasculature connection and perfusion are: (1) Engineered 3D tissues with endothelial cell (EC) networks, (2) compatibility of endothelial cells, (3) exogenous scaffold stiffness, and (4) mesenchymal cell co-cultivation. The transparent circles were indicated as mesenchymal cells. The green circles were indicated as ECs.